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St. Louis Metro Edition A Health Review for the Gateway Region Evergreen Guides · Reviewed 2026
The

Gateway Health Review

Considered reporting on mental health care across St. Louis and St. Charles County.

The Cover Story · Treatment-Resistant Depression

When the medication was supposed to be the answer, and it was not.

Depression · The Long Read

When antidepressants stop working, the next step is a conversation, not a dead end

For a meaningful share of people, the first, second, or even third medication does not lift the fog. What treatment-resistant depression really means, and the serious options that exist for readers across the Gateway region.

From the Desks
Treatment · Esketamine

Spravato, explained without the hype

One of the first genuinely new mechanisms for depression in a generation. What a Spravato appointment actually involves, and what it is not.

PTSD & Anxiety

The anxiety that will not switch off

Post-traumatic stress and chronic anxiety rarely travel alone. How they overlap with depression, and where Gateway-region readers can turn.

Insurance / Cost

Paying for care, including MO HealthNet

Cost is the quiet reason many people never start. What insurance and Medicaid can do, and the questions that keep you from overpaying.